We also found a substantial dupilumab-associated reduction in the level of TARC, a key Th2 biomarker. Both the levels of TARC and the change in the levels were considerably correlated with actions of pruritus during the study. Pretreatment degrees of serum total IgE, TARC, and peripheral eosinophilia were not predictive of a medical response to dupilumab highly. Dupilumab blocks the actions of the Th2 cytokines interleukin-13 and interleukin-4. The outcomes of the studies reported here expand the potential good thing about this new biologic therapy beyond asthma to a second atopic disorder, atopic dermatitis.19 Dupilumab treatment led to highly reproducible improvements across all clinical end points when the drug was administered as monotherapy and, more so even, when it was combined with topical glucocorticoids.Our findings present that adjusting mortality for reliability reduces statistical noise and provides more stable estimates of hospital quality. .
22otters launches HerStory app that enables women to talk about health advice, tales with each other HerStory, a new smartphone app that allows women to share health stories and advice with each other, was launched by 22otters recently, a Khosla Ventures-funded digital wellness startup ( Research implies that listening to and speaking personal stories is usually therapeutic. The HerStory app can be a safe place for women to share their encounters with others by using their voices to record supportive personal stories and practical tips.