The federal government Centers for Disease Control and Prevention recommends all people over the age of 50 get a flu vaccination. Individuals 50 and older are more vulnerable to seasonal flu and its complications, and should get vaccinated as because they can soon. The seasonal flu vaccine is preferred for home caregivers of young children especially, the elderly, and other people at risky of flu complications. According to the CDC, the flu vaccine has been proven to be 70-90 percent effective in preventing the flu in healthful individuals beneath the age of 65. For older individuals who are living in the city, it is 30-70 percent effective in preventing hospitalization from the flu. For individuals who reside in long term care facilities, the vaccine provides been proven to be 50-60 percent effective in stopping hospitalization and 80 percent effective in preventing loss of life from the flu..Hsieh, M.D., Elizabeth M. Kang, M.D., Courtney D. Fitzhugh, M.D., M. Beth Link, R.N., Charles D. Bolan, M.D., Roger Kurlander, M.D., Richard W. Childs, M.D., Griffin P. Rodgers, M.D., Jonathan D. Powell, M.D., Ph.D., and John F. Tisdale, M.D.1,2 This noticeable transformation causes a propensity toward polymerization of hemoglobin and, hence, sickle-shaped crimson cells. Anemia, improved hemolysis, and chronic and acute vaso-occlusive problems that affect multiple organs are the main features of sickle cell disease. At the moment, allogeneic hematopoietic stem-cell transplantation may be the only curative option.3-5 Approximately 200 children have undergone this process after myeloablative conditioning with busulfan and cyclophosphamide, with or without antithymocyte globulin, producing a rate of disease-free survival of 95 percent in the newest series.5 After transplantation, the donor’s hematopoietic cells completely change those of the recipient generally in most children who undergo this process, but some continue steadily to have both recipient and donor cells in the blood vessels .6 This mix is sufficient to reverse the sickle cell disease phenotype.